ABSTRACT
BACKGROUND: Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology. AIM: To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS. METHODS: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men). RESULTS: The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers. CONCLUSIONS: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.
Subject(s)
Adolescent , Adult , Anxiety/metabolism , Biomarkers/blood , Colonic Diseases, Functional/complications , Diarrhea/complications , Humans , India , Male , Middle Aged , Monoamine Oxidase/metabolism , Serotonin/metabolism , Statistics as TopicABSTRACT
Amavata which is popularly correlated with Rheumatoid disease, is characterised by its eternal course, uncertain progression and unpredictable series of exacerbations and remissions. In Ayurveda the impact of the Amavata over psychological setup of the patient is well recognised. Satvavajaya therapy of Ayurveda may be considered as a kind of patient education in rheumatology but with much broader base and much better applicability.